Mio may refer to:
- Mio Amakura, the protagonist from Fatal Frame II: Crimson Butterfly, appearing as:
- A combined trophy with Mayu Amakura in Super Smash Bros. for Wii U.
- A combined spirit with Mayu Amakura in Ultimate.
- Mio, the protagonist from Xenoblade Chronicles 3, appearing as a combined spirit with Noah.
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