Metroid Prime is a video game developed by Retro Studios and published by Nintendo for the Nintendo GameCube, released in North America on November 15, 2002. It is the first 3D game in the Metroid series, and is classified by Nintendo as a first-person adventure rather than a first-person shooter, due to the large exploration component of the game.

In "Super Smash Bros Brawl"

The first location the player visits in the game, Frigate Orpheon, is a stage in Super Smash Bros Brawl. Also, the Parasite Queen, a boss from the game, appears as a background character.

Meta-Ridley, the cybernetic version of Ridley in the Subspace Emissary, first appeared in this game.

The credits theme is a available song in the Frigate Orpheon stage.